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主题:【原创】送给孝子:骨质疏松 -- 虽远必诛

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家园 多胎妊娠会导致骨质流失更快

有证据吗?

家园 老大,食补管不管用

比如常喝骨头汤。

家园 想喝就喝,没有什么大用处的

骨头汤里面的钙,少的可怜。

含钙量最高的药物是碳酸钙CaCO3 达到40%。但是不是水溶的。

另外单纯补钙对BMD影响不大。

您相信吃那补那就吃,没有坏处。

也没有什么大用处。

家园 这个学的倒是快

a prospective study of bone mineral density (BMD) in 38 women during their first full-term pregnancy until 12 months postpartum. BMD measurements at lumbar spine [L2–L4 (LS)] and forearm [distal 33% (RD) and ultradistal (RUD) region of the radius] were made within 3 months before conception, after delivery, and at 6 and 12 months postpartum. In mid-pregnancy the DXA examination was carried out only at the forearm. Patients were grouped according to duration of lactation as group I, II or III (0–1, 1–6, 6–12 months respectively). During pregnancy there was a significant difference between baseline and delivery (p< 0.001) in the LS, RUD and RD BMD values. In group I there was no statistically significant difference in LS BMD between visits following pregnancy. The RUD BMD loss was recovered by 6 months postpartum (PP6). Group II showed continuous bone loss from delivery until PP6 at LS and RUD. In group III the LS BMD loss continued throughout the lactation period. The RUD BMD dropped (4.9%) until PP6 then increased by 3.0% as measured at 12 months postpartum (PP12). There was no significant change in RD BMD in any of three groups during lactation. At LS bone loss between delivery and PP12 correlated well with the duration of lactation (r=0.727; p<0.001). We suggest that calcium needed for fetal skeletal growth during pregnancy was gained from maternal trabecular and cortical sites and that calcium needed for infant growth during lactation was drawn mainly from the maternal trabecular skeleton in our patients. The effect of pregnancy and lactation on the maternal bone mass was spontaneously compensated after weaning.

The Effects of Pregnancy and Lactation on Bone Mineral Density C. More1, P. Bettembuk, H. P. Bhattoa and A. Balogh osteoporosis international 2004,04

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家园 呵呵,这个证据不容易拿出来的

寿命的研究必然不如医学采样研究那么细致,科学。毕竟没有哪个老不死可以横跨几个世纪去完成如此复杂的研究。

或者说,严谨的研究可能要一百多年后才能得出肯定的结论。

Women who had "late fertility" - a birth at age 45 or older - were 14 percent to 17 percent less likely to die during any year after age 50 than women who did not deliver a child after age 40. That confirmed earlier studies. But those studies did not determine if the women gave birth later and lived longer because of genes or because of social and environmental factors such as good nutrition or healthy living.

Brothers who had at least three sisters, including at least one sister who gave birth at age 45 or later, were 20 percent to 22 percent less likely to die during any year after age 50 than brothers who had no "late fertile" sisters. That indicates what earlier studies did not, namely, the same genes may influence the lifespan of both sexes and women's ability to give birth at older ages.

Late motherhood boosts family lifespan

家园 虽远大夫你好

请问经常饮用牛奶是否对老年骨质疏松有预防或者治疗作用?我母亲前两年经常感觉肌肉酸痛无力,走路时经常性突然腿软,后来我劝他们订了牛奶每天早晨饮用,貌似有一定效果。

家园 这个新闻肯定没有经过临床数据收集阶段

英国每日电讯报的这则报道却在中国流传很广。

Late motherhood could hold the secret to longevity

"The baby boomers of today are doing the right thing by having children much later - because the evidence is that the later you produce children, the longer your life span will be," said Dr Dawn Skelton of Manchester University, a leading authority on ageing.

She tells a television documentary to be shown next month: "After 30, there is a dramatic reduction of the oestrogen hormone in women. By leaving it longer before having our first child, we're giving ourselves a big burst of oestrogen, which helps in many ways - muscle, bone, nervous function."

过了一年,它又炒了次冷饭:

Dramatic rise in fortysomething mother

Later motherhood holds benefits as well as drawbacks. Older women find it more tiring but it also seems to bring longevity.

家园 这种商业报纸的报道,没有任何临床价值

要看在专业期刊上的,尤其是知名的期刊。如果cochrane review 说的,那么就可以作为定论了。

家园 没有帮助

牛奶中的钙含量更低了,而单纯钙是没有的。

钙+D会好一些,但是没有特殊意义。

最好的是Loading 的锻炼。

至于腿软,同骨质疏松关系不大,是肌肉力量的问题,还要考虑OA。

家园 你这个定义很狭窄,但人生苦短,等不到

这些杂志研究出规律。

但却有人发现女性百岁老人多有过四十生育的历史:

In their studies of centenarians, Perls and Fretts found that a surprising number of women who lived to be 100 or more gave birth in their forties. These 100-year-old women were four times as likely to have given birth in their forties as women born in the same year who died at age 73. A study of centenarians in Europe by the Max Planck Institute of Demography in Germany found the same relationship between longevity and fecundity.

Why Women Live Longer than Men

这个大概不是商业炒作吧?

家园 假定此研究的对象是机器人,那么可能的推论当然是

生得越多,骨质越疏松,自然寿命也越短。

但是人类研究自然不能从一个短期内就得出肯定的结论。

倒是有相反的证据,波士顿医学院的新英格兰百岁老人研究表明:多生晚生有利于长寿。

Many centenarian women have a history of bearing children after the age of 35 years and even 40 years. From our studies, a woman who naturally has a child after the age of 40 has a 4 times greater chance of living to 100 compared to women who do not (6). It is probably not the act of bearing a child in one’s forties that promotes long life, but rather, doing so may be an indicator that the woman’s reproductive system is aging slowly and that the rest of her body is as well. Such slow aging and the avoidance or delay of diseases that adversely impact reproduction would bode well for the woman’s subsequent ability to achieve very old age.

New England Centenarian Study

家园 谢谢您的回答

不过也奇怪了,自从我给她订牛奶每天饮用后据她自己讲症状明显减轻,究竟是在安慰我呢还是心理作用?

家园 很大程度上是安慰你作用

老人都非常体谅儿女的孝心。如果您费了心思他们说没有用是很伤您的心,您说对不对。

对他们自的安慰剂效应也有,而且有的时候非常明显,比如说Glucosamine。

另外疼痛本身是绝对主观的指标,参看以前写的痛和痛觉。

喝牛奶不会明显改变骨质疏松,这个可以直接检查的指标。

家园 请教:福善美效果如何

现在老年人很多用这个.

家园 已经介绍了

福善美 10毫克 Alendronate(阿伦倔酸), bisphosphonates(二磷酸类)。

就是文中提到骨膦类。

是明确可以提高骨密度的,但是不推荐常规使用。

第一:是处方用药,不能自己用,要在医生指导下使用。 

第二:对于重症的效果好,普通的正常生理流失,反而效果不是特殊明显。

第三:副作用明显,消化道,体位性低血压,骨坏死等等。

目前推荐常规的生理性骨质疏松的治疗还是合理锻炼为第一,适当补充钙+D第二。重症去看医生,才用到这个。

实际上,这可以看成两个不同的疾病,生理性骨质疏松--保守非药物治疗最好。

重症的明细病理改变的,要在医生指导下用药。

千万别自己用药。

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