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主题:【原创】南乡子- 留美生物博后 -- 把酒酹青天

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                  • 家园 molecular dynamics simulatio

                    呵呵,俺是从来没有这个想法。计算不过是个手段罢了,有优点也有缺点。

                    之所以现在有人为计算而计算是因为很多做计算和工程的童鞋们忽然发现自己的东西可以在life science里用罢了,再说谁不知道NIH的钱比NSF多的不是一点儿半点儿。前俩月,NIH散了不少钱吧,据说拿到的运气已经可以和买彩票差不多了,很好奇哪找那么多reviewer哈。

                    • 家园 就是gene regulatory networks吧

                      根據基因表達在時間上的分布做邏輯模型。您是做這方面的工作嗎?

                      • 家园 不是,那东西大概属于Bioinfo

                        很多统计的东西,MD是Comp Bio,核心是数值分析之类的东西,比较接近物理。是一个和具体实验非常紧密的技术,大部分是蛋白质,就是一个计算机模拟,用来观测动态过程的。

                        • 家园 這個很有意思呀

                          計算技術方面,按照我的理解,應該就是動態過程仿真哪一類型吧。

                          但是在前期收集數據的過程中,目前怎樣做到在實驗中檢測細胞里蛋白質動態的變化呢?是標記熒光,還是常規生化檢測?

                          • 家园 实验跟模拟是两条路

                            MD只需要明确的蛋白结构和溶液环境就可以了,只是在结果的解释上,需要和实验技术参照,以确定其对原子水平细节的描述合理。

      • 家园 嘛是计算生物学?咋没听过呢
        • 家园 估计是Bioinformatics

          热了有几年了。

          • 家园 computational biology

            范围很广的,确切的抠字眼的话,生物信息只能说是其中的一块,也就是跟计算机领域的信息学相关的那块。我说的那个人不是做生物信息的,他做的大概属于modelling或者simulation一类。

            抄段wiki:

            Computational biology is an interdisciplinary field that applies the techniques of computer science, applied mathematics and statistics to address biological problems. It encompasses the fields of:

            * Bioinformatics, which applies algorithms and statistical techniques to the interpretation, classification and understanding of biological datasets. These typically consist of large numbers of DNA, RNA, or protein sequences. Sequence alignment is used to assemble the datasets for analysis. Comparisons of homologous sequences, gene finding, and prediction of gene expression are the most common techniques used on assembled datasets; however, analysis of such datasets have many applications throughout all fields of biology.

            * Computational biomodeling, a field within biocybernetics concerned with building computational models of biological systems.

            * Computational genomics, a field within genomics which studies the genomes of cells and organisms. High-throughput genome sequencing produces lots of data, which requires extensive post-processing (genome assembly) and uses DNA microarray technologies to perform statistical analyses on the genes expressed in individual cell types. This can help find genes of interests for certain diseases or conditions. This field also studies the mathematical foundations of sequencing.

            * Molecular modeling, which consists of modelling the behaviour of molecules of biological importance.

            * Protein structure prediction and structural genomics, which attempt to systematically produce accurate structural models for three-dimensional protein structures that have not been determined experimentally.

            * Computational biochemistry and biophysics, which make extensive use of structural modeling and simulation methods such as molecular dynamics and Monte Carlo method-inspired Boltzmann sampling methods in an attempt to elucidate the kinetics and thermodynamics of protein functions.

            这段基本上是准确的,就是structural genomics应该是两块,一大块是实验方法,另小一块才是这儿说的计算生物学的方法——而这个计算方法,似乎就是前面半句说的“Protein structure prediction”。当然你把这个omics给人家拿掉了,人家要不高兴的

    • 家园 奥巴马刺激政策,今年的fungding多,而且好像比

      比以往容易。。。

      要混教授,还是先到牛校做博后,认识大牛。然后到小地方学校,混终身。。。。

    • 家园 生物是21世纪的学科,人类发展的明灯呀。。。。

      多好。。。

      你看现在搞生物的大把FUNDING, 搞IT的都是民工!

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