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主题:【原创】南乡子- 留美生物博后 -- 把酒酹青天

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家园 computational biology

范围很广的,确切的抠字眼的话,生物信息只能说是其中的一块,也就是跟计算机领域的信息学相关的那块。我说的那个人不是做生物信息的,他做的大概属于modelling或者simulation一类。

抄段wiki:

Computational biology is an interdisciplinary field that applies the techniques of computer science, applied mathematics and statistics to address biological problems. It encompasses the fields of:

* Bioinformatics, which applies algorithms and statistical techniques to the interpretation, classification and understanding of biological datasets. These typically consist of large numbers of DNA, RNA, or protein sequences. Sequence alignment is used to assemble the datasets for analysis. Comparisons of homologous sequences, gene finding, and prediction of gene expression are the most common techniques used on assembled datasets; however, analysis of such datasets have many applications throughout all fields of biology.

* Computational biomodeling, a field within biocybernetics concerned with building computational models of biological systems.

* Computational genomics, a field within genomics which studies the genomes of cells and organisms. High-throughput genome sequencing produces lots of data, which requires extensive post-processing (genome assembly) and uses DNA microarray technologies to perform statistical analyses on the genes expressed in individual cell types. This can help find genes of interests for certain diseases or conditions. This field also studies the mathematical foundations of sequencing.

* Molecular modeling, which consists of modelling the behaviour of molecules of biological importance.

* Protein structure prediction and structural genomics, which attempt to systematically produce accurate structural models for three-dimensional protein structures that have not been determined experimentally.

* Computational biochemistry and biophysics, which make extensive use of structural modeling and simulation methods such as molecular dynamics and Monte Carlo method-inspired Boltzmann sampling methods in an attempt to elucidate the kinetics and thermodynamics of protein functions.

这段基本上是准确的,就是structural genomics应该是两块,一大块是实验方法,另小一块才是这儿说的计算生物学的方法——而这个计算方法,似乎就是前面半句说的“Protein structure prediction”。当然你把这个omics给人家拿掉了,人家要不高兴的

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