主题：【原创】胖子们的接班人问题――关于儿童肥胖 -- 青方

Biochemical mechanisms for developing acanthosis nigricans involve significant insulin resistance at the cellular level, with compensatory hyperinsulinemia. Hyperinsulinemia stimulates insulin-like growth factor receptors, with a subsequent induction of keratinocyte proliferation.A number of treatments have been attempted for acanthosis nigricans, including topical tazarotene, metformin, octapeptide, troglitazone, and topical calciptriol. Diet control as a means of reducing insulin resistance is also useful.Diabetes, if present, should be treated with intensive lifestyle alteration (decreasing caloric intake and increasing physical activity). Metformin is the oral agent of choice. Insulin secretagogues and insulin injections may exacerbate acanthosis nigricans.

"Obesity and dermatology"

Noah S. Scheinfeld MD, JD,

the Department of Dermatology, St. Luke's–Roosevelt Hospital Center and Beth Israel Medical Center, New York, New York, USA.

Clinics in Dermatology

Volume 22, Issue 4 , July-August 2004, Pages 303-309