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主题:Cell这次一锤定音,东亚人的ACE2表达频率 -- 陈王奋起

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家园 您是怎么读的文章

英文那么好,应该全文读透啊,不要断章取义乱带节奏。文章明明做的是ACE2在不同人群中的变异的频率,图反应的是中国和中亚地区的人群ACE2基因上不同位点的变异频率比较高而已,潜在的可能是这些变异有可能导致不同的人对病毒感染及应答有差别。图中没有涉及任何表达量的问题。

这是作者的结论,人家明确说没有证据支持不同人群有抵抗病毒结合的突变,写的明明白白。这么乱带节奏,好吗?

In summary, we systematically analyzed coding-region variants in ACE2 and the eQTL variants, which may affect the expression of ACE2 using the GTEx database to compare the genomic characteristics of ACE2 among different populations. Our findings indicated that no direct evidence was identified genetically supporting the existence of coronavirus S-protein binding-resistant ACE2 mutants in different populations (Fig. 1a). The data of variant distribution and AFs may contribute to the further investigations of ACE2, including its roles in acute lung injury and lung function12. The East Asian populations have much higher AFs in the eQTL variants associated with higher ACE2 expression in tissues (Fig. 1c), which may suggest different susceptibility or response to 2019-nCoV/SARS-CoV-2 from different populations under the similar conditions.

通宝推:龙牡,
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