主题：《茗谈92》：搭桥 -- 本嘉明

Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1443-8. Epub 2007 Jul 10.

Dietary patterns and breast cancer risk in the shanghai breast cancer study.

Cui X, Dai Q, Tseng M, Shu XO, Gao YT, Zheng W.

Source

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

Abstract

The association of breast cancer with dietary patterns such as a western diet has not been studied in Asian women. We examined this among Shanghai Breast Cancer Study participants. Cases were of ages 25 to 64 years, diagnosed 08/1996-03/1998, and identified through a rapid case ascertainment system supplemented by the Shanghai Cancer Registry. Controls, selected from the general population of urban Shanghai, were frequency matched to cases by 5-year age group. Participants provided information on diet, lifestyle, and reproductive factors. In principal component analysis among 1,556 controls, two patterns emerged: a "vegetable-soy" pattern (tofu, cauliflower, beans, bean sprouts, green leafy vegetables) and a "meat-sweet" pattern (shrimp, chicken, beef, pork, candy, desserts). In adjusted unconditional logistic regression analyses including 1,446 cases and 1,549 controls with complete covariate data, risk was not associated with the vegetable-soy pattern. It was associated with the meat-sweet pattern (4th versus 1st quartile: odds ratio, 1.3; 95% confidence interval, 1.0-1.7; P(trend) = 0.03), but only in postmenopausal women, specifically among those with estrogen receptor-positive tumors (4th versus 1st quartile: odds ratio, 1.9; 95% confidence interval, 1.1-3.3; P(trend) = 0.03). Our findings indicate that a western diet increases breast cancer risk in postmenopausal Chinese women. They also suggest the value of quantifying aggregate risk for common combinations of foods.

再看一下这个流行病学调查研究的数据（Cancer Causes Control. 2010 Nov;21(11):1777-85. Recent trends and patterns in breast cancer incidence among Eastern and Southeastern Asian women.Shin HR, Joubert C, Boniol M, et al.）吧：

年龄20–34、35–49、50–69和70岁以上几个年龄段的乳腺癌发病率在中国农村（嘉善、启东）分别为每十万妇女2.4、27.3、32.2、23.3，在上海分别为4.9、64.7、92.2、96.6。你觉得这个数据可以说明中国乳腺癌到底是绝经前多还是绝经后多吗？可以说明西方生活方式对中国乳腺癌的影响吗？

你还可以去搜几篇关于豆制品或大豆异黄酮对乳腺癌患者预后影响的文章，看看究竟饮食和乳腺癌有没有关系，再来这里讨论，OK?