主题：【整理】新冠后遗症 -- 菜根谭

HIV 和 SARS-CoV-2 是我们这个时代最危险和威胁生命的两种传染病的罪魁祸首。为了更好地分析两种感染引起的免疫反应的差异，我们比较了通过流式细胞术分析 (FCA) 测量的 AIDS 和 COVID-19 患者的淋巴细胞亚群的变化，这些患者转诊至我们的大学医院。对总共 184 名 HIV 感染患者进行了回顾性检查，收集了 FCA 的结果，并与在实际爆发期间检查的 110 名 SARS-CoV-2 感染患者中获得的结果进行了比较。与 AIDS 患者相比，我们观察到两种疾病中 B 细胞的减少相当，而 COVID-19 中 T 细胞的总量减少更严重。对 T 细胞亚群的分析表明，CD4+ 细胞计数有相当程度的减少。相反，在 CD8+ 计数中观察到它们之间的显着差异。在 AIDS 患者中，CD8+ 细胞比正常人略高，而在 COVID-19 患者中，CD8+ 细胞计数显着减少。因此，CD4+/CD8+ 比率在 AIDS 中非常低，在 COVID-19 患者中高于正常值。这两种疾病的 NK 细胞都减少了，但与 HIV 感染相比，SARS-CoV-2 感染会导致更严重的减少。总之，HIV 和 SARS-CoV-2 病毒都会引起淋巴细胞计数的重大变化，它们之间存在显着的相似性和差异性。与艾滋病患者相比，COVID-19 患者的 T 细胞总数，尤其是 CD8+ 亚群的绝对数量较低，而 CD4+ 在两者中都以相似的水平减少。这些结果表明宿主免疫系统对这两种感染的反应不同，但它们对 CD4+ T 细胞群的血清水平有相当的下降作用。讨论了 T 细胞活化和血清消耗方面的相似性和差异的意义。关于免疫系统如何对这两种感染作出反应的知识将有助于更好地定义它们的作用机制并设计特定的预防和治疗方法。讨论了 T 细胞活化和血清消耗方面的相似性和差异的意义。关于免疫系统如何对这两种感染作出反应的知识将有助于更好地定义它们的作用机制并设计特定的预防和治疗方法。讨论了 T 细胞活化和血清消耗方面的相似性和差异的意义。关于免疫系统如何对这两种感染作出反应的知识将有助于更好地定义它们的作用机制并设计特定的预防和治疗方法。

HIV and SARS-CoV-2 are responsible for two of the most dangerous and life-threatening infectious diseases of our times. To better analyze the difference in the immunological response elicited by the two infections, we compare the alterations in the lymphocyte subpopulations, measured by flow cytometry analysis (FCA) in both AIDS and COVID-19 patients, referred to our University Hospital. A total of 184 HIV infected patients were retrospectively examined and the results of FCA collected and compared to those obtained in 110 SARS-CoV-2 infected patients, examined during the actual outbreak. We observe a comparable reduction in B cells in both diseases and a more severe reduction in the total amount of T cells in COVID-19 as compared to AIDS patients. The analysis of the T cells subpopulations indicates that there is a comparable reduction in the CD4+ cells count. Conversely, a remarkable difference between them is observed in the CD8+ counts. In AIDS patients the CD8+ cells are slightly higher than normal, while in COVID-19 patients the CD8+ cell count is markedly reduced. As a result, the CD4+/CD8+ ratios, is very low in AIDS and higher than normal in COVID-19 patients. The NK cells are reduced in both diseases, but SARS-CoV-2 infection causes a more severe reduction compared to HIV infection. In conclusion, both HIV and SARS-CoV-2 viruses induce major changes in the lymphocytes count, with remarkable similarities and differences between them. The total absolute numbers of T cells and, in particular of the CD8+ subpopulation, are lower in COVID-19 patients compared to AIDS ones, while the CD4+ are reduced in both at similar levels. These results indicate that the host immune system reacts differently to the two infection, but they are responsible of a comparable dropping effect on the serum levels of CD4+ T cell population. The meaning of the similarities and of the differences in terms of T cells activation and serum depletion are discussed. The knowledge on how the immune system reacts to these two infections will be useful to better define their mechanism of action and to design specific preventive and therapeutic approaches.

复跟胶白兄讨论一下

家园

你叫不醒装睡的人

这个楼主在新冠后遗症问题上，不是第一次出问题了：就是主观故意的夸大、误导。一篇论文，一个报道读不懂不奇怪，每篇论文都能读不懂，而且是朝一个方向读不懂，肯定是主观问题。

随着中国大规模的感染，大家很快就能知道真实情况。这种投机者必将遭到唾弃。

复新冠对免疫力的破坏与重复感染

家园

没听说印度现在有什么问题啊

照你说的

印度现在又应该有几波了

复没听说印度现在有什么问题啊

家园