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Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting.

Magen Ori et al. The New England journal of medicine 2022-04

https://pubmed.ncbi.nlm.nih.gov/35417631

The primary analysis included 182,122 matched pairs.

Relative vaccine effectiveness in days 7 to 30 after the fourth dose was estimated to be

阻止传染: 45% (95% confidence interval [CI], 44 to 47) against polymerase-chain-reaction–confirmed SARS-CoV-2 infection,

55% (95% CI, 53 to 58) against symptomatic Covid-19,

68% (95% CI, 59 to 74) against Covid-19–related hospitalization,

62% (95% CI, 50 to 74) against severe Covid-19, and

阻止死亡: 74% (95% CI, 50 to 90) against Covid-19–related death.

The corresponding estimates in days 14 to 30 after the fourth dose were

52% (95% CI, 49 to 54),

61% (95% CI, 58 to 64),

72% (95% CI, 63 to 79),

64% (95% CI, 48 to 77), and

76% (95% CI, 48 to 91)